Gene-Gene Interaction in Maternal and Perinatal Research
نویسندگان
چکیده
1Departments of Biomathematics and Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA 2Department of Biostatistics, School of Public Health, UCLA, Los Angeles, CA 90095, USA 3Division of Genetic and Molecular Epidemiology, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA 4The Computational Genomics Lab, Department of Epidemiology, Michigan State University, East Lansing, MI 48824, USA
منابع مشابه
P-127: Characterization of Filia, A Maternal Effect Gene, in Bovine Oocytes and Embryos
Background: Genetic analysis in mice has lead to find about maternal effect genes such as Filia. Filia knock out mice have a 50% decrease in fertility. Filia dysfunction causes disorders in pre-implantation development. Mutations in human Filia gene, cause FBHM (Familial Biparental Hydatidiform Mole) in women. Filia protein in mice is homologous to that of rat and human, so this idea has emerge...
متن کاملIdentification and prioritization genes related to Hypercholesterolemia QTLs using gene ontology and protein interaction networks
Gene identification represents the first step to a better understanding of the physiological role of the underlying protein and disease pathways, which in turn serves as a starting point for developing therapeutic interventions. Familial hypercholesterolemia is a hereditary metabolic disorder characterized by high low-density lipoprotein cholesterol levels. Hypercholesterolemia is a quantitativ...
متن کاملP-90: Maternal Susceptibility to Pre-Eclampsia in South Indian Women: FOXP3 Gene
Background: Pre-eclampsia is a multifactorial pregnancy specific vascular disorder characterized by hypertension and proteinuria. It affects around 3-5% pregnancies worldwide. The aetiology and pathophysiology of PE remain poorly understood. But it is generally accepted defective placentation during the early stage of pregnancy most likely in combination with maternal and environmental factors ...
متن کاملAssociation of Combined Maternal-Fetal TNF-α Gene G308A Genotypes with Preterm Delivery: A Gene-Gene Interaction Study
Preterm delivery (PTD) is a complicated perinatal adverse event. We were interested in association of G308A polymorphism in tumor necrosis factor-alpha (TNF-alpha) gene with PTD; so we conducted a genetic epidemiology study in Anqing City, Anhui Province, China. Case families and control families were all collected between July 1999 and June 2002. To control potential population stratification ...
متن کاملThe aerobic maternal exercise increases PDK4 gene expression in slow and fast twitch muscles of rat male offspring.
Recent studies indicate that environment can modify skeletal muscle gene expression and transcriptional factors in offspring genes. Therefore, exercising can lead to changes in the gene expression of the future generations. One of the important metabolic factors is PDK4, which is known as the main factor in Pyruvate Dehydrogenase Complex (PDC). This study examined the effects of maternal exerci...
متن کاملAge-dependent role of pre- and perinatal factors in interaction with genes on ADHD symptoms across adolescence.
Little is known about the effects of risk factors on attention-deficit/hyperactivity disorder (ADHD) symptom over time. Here, we longitudinally studied the role of candidate genes, pre- and perinatal factors, and their interactions on ADHD symptoms between ages 10 and 18 years. Subjects were part of the general population or clinic-referred cohort of the TRacking Adolescents' Individual Lives S...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 2010 شماره
صفحات -
تاریخ انتشار 2010